Using atomic force microscopy (AFM) to study the aggregation of amyloid proteins, specifically amyloid beta, islet amyloid polypeptide, and fragments thereof.
Max received his B.S. in Chemistry from Santa Clara University in 2012. His undergraduate research was done in the labs of Brian McNelis and Richard Barber where he synthesized fullerene derivatives and investigated their effects on the lifetime of bulk-heterojunction solar photovoltaic devices. His current work in the Buratto group is focused on determining the aggregation pathways of amyloid proteins using atomic force microscopy.
Illitchev, A.I.; Giammona, M.J.; Do, T.D.; Wong, A.G.; Buratto, S.K.; Shea, J.; Raleigh, D.P.; Bowers, M.T. Human Islet Amyloid Polypeptide N-Terminus Fragment Self-Assembly: Effect of Conserved Disulfide Bond on Aggregation Propensity. J. Am. Soc. Mass Spectrom. 2016, DOI: 10.1007/s13361-016-1347-7
Economou, N.E.; Giammona, M.J.; Do, T.D.; Zheng, X.; Teplow, D.B.; Buratto, S.K.; Bowers, M.T. Amyloid ?-Protein Assembly and Alzheimer’s Disease: Dodecamers of A?42, but Not of A?40, Seed Fibril Formation. JACS 2016 138 (6), 1772
Tro, M.; Sarabia, A.; Bandaccari, K. J.; Oparko, D.; Lewis, E.; Giammona, M. J.; Isaac, J.; Valverde, P.T.; Chesmore, G.E.; Adalsteinsson, T.; Barber, R.P.; McNelis, B.J. Structure-function relationship of fullerene esters in polymer solar cells: unexpected structural effeccts on lifetime and efficiency. Int. J. Energy Res. 2015 DOI: 10.1002/er.3463
Sena, E. L.; Peel, J. H.; Wesenberg, D.; Nathan, S.; Wallis, M.; Giammona, M. J.; Adalsteinsson, T.; McNelis, B. J.; Barber, R. P. Transport and spectroscopic studies of the effects of fullerene structure on the efficiency and lifetime of polythiophene-based solar cells. Solar Energy Materials and Solar Cells 2012, 100, 192